abstract：:Depression is associated with a dysfunctional serotonin (5-hydroxytryptamine; 5-HT) system. More recently, several lines of evidence suggest that an important factor in the development of depression may be a deficit in the function and expression of 5-HT1A receptors. The present study assessed ifNelumbinis Semen (N. s...

journal_title：Archives of pharmacal research

authors： Jang CG,Kang M,Cho JH,Lee SB,Kim H,Park S,Lee J,Park SK,Hong M,Shin MK,Shim IS,Bae H

更新日期：2004-10-01 00:00:00

abstract：:Four compounds were isolated from Salicornia herbacea by repeated column chromatography. Their structures were identified as beta-sitosterol (1), stigmasterol (2), uracil (3), and isorhamnetin-3-O-beta-D-glucopyranoside (4) by spectral analysis and comparison with the published data. ...

journal_title：Archives of pharmacal research

authors： Lee YS,Lee HS,Shin KH,Kim BK,Lee S

更新日期：2004-10-01 00:00:00

abstract：:By bioassay-guided separation, an already known saponin, Pulsatilla saponin D was isolated from the root of Pulsatilla koreana Nakai as a antitumor component when evaluated by in vivo antitumor activity as well as in vitro cytotoxic activity test. It showed potent inhibition rate of tumor growth (IR, 82%) at the dose ...

journal_title：Archives of pharmacal research

authors： Kim Y,Bang SC,Lee JH,Ahn BZ

更新日期：2004-09-01 00:00:00

abstract：:Carvedilol is administered as a racemic mixture of the R(+)- and S(-)-enantiomers, although they exhibit different pharmacological effects. To investigate the stereoselective pharmacokinetics, the enantiomeric separation of carvedilol in human plasma was undertaken using capillary electrophoresis (CE). Resolution of t...

journal_title：Archives of pharmacal research

authors： Phuong NT,Lee BJ,Choi JK,Kang JS,Kwon KI

更新日期：2004-09-01 00:00:00

abstract：:Many diselenide compounds are used as antioxidants, enzyme inhibitors and cytokine inducers. Three new diselenide compounds, bis-(2-hydroxyphenyl) diselenide, bis-(3-hydroxyphenyl) diselenide and bis-(4-hydroxyphenyl) diselenide were designed and synthesized as anti-inflammatory agent. All of them were found to have s...

journal_title：Archives of pharmacal research

authors： Shen L,Shin KM,Lee KT,Jeong JH

更新日期：2004-08-01 00:00:00

abstract：:Oxidative stress due to reactive oxygen species (ROS) can cause oxidative damage to cells. Cells have a number of defense mechanisms to protect themselves from the toxicity of ROS. Mitochondria are especially important in the oxidative stress as ROS have been found to be constantly generated as an endogen threat. Mito...

journal_title：Archives of pharmacal research

authors： Ha BJ

更新日期：2004-08-01 00:00:00

abstract：:5,8-Epidioxycholest-6-en-3-ol (1), cholesterol (2), glycerol 1-palmitate (3) and glycerol 1,3-dioleate-2-stearate (4) were isolated from the methanol extract of the sea urchin Diadema setosum, which was collected from the Halong sea, Vietnam. Chemical structures were established based on extensive 1D, 2D-NMR, FAB-MS, ...

journal_title：Archives of pharmacal research

authors： Minh CV,Kiem PV,Huong le M,Kim YH

更新日期：2004-07-01 00:00:00

abstract：:LPD vectors are non-viral vehicles for gene delivery comprised of polycation-condensed plasmid DNA and liposomes. Here, we described a novel anionic LPD formulation containing protamine-DNA complexes and pH sensitive liposomes composed of DOPE and cholesteryl hemisuccinate (Chems). Central composite design (CCD) was e...

journal_title：Archives of pharmacal research

authors： Sun X,Zhang Z

更新日期：2004-07-01 00:00:00

abstract：:A new indolinepeptide (3) was isolated, together with two known compounds, a cerebroside (1) and an alloxazine (2), from silkworm larvae infected with Paecilomyces sp. J300. On the basis of spectroscopic data, their structures were elucidated as (4E, 8E, 2S, 2'R, 3R)-N-2'-hydroxyhexadecanoyl-1-O-beta-D-glucopyranosyl-...

journal_title：Archives of pharmacal research

authors： Kwon HC,Kim KR,Zee SD,Cho SY,Lee KR

更新日期：2004-06-01 00:00:00

abstract：:The highly water-soluble monomethoxypoly(ethyleneglycol) (mPEG) prodrugs of cyclosporin A (CsA) were synthesized. These prodrugs were prepared by initially preparing intermediate in the form of carbonate at the 3'-positions of CsA with chloromethyl chloroformate, in the presence of a base to provide a 3'-carbonated Cs...

journal_title：Archives of pharmacal research

authors： Cho H,Chung Y

更新日期：2004-06-01 00:00:00

abstract：:In this study, a series of 4-amino-5-cyano-3-substituted-2,3-dihydrothiazol-2-thiones (1a-c), as well as their triazolo and triazinopyrimidine derivatives such as 8-substituted-3-benzyl-5-methylthiazolo[5,4-e][1,2,4] triazolo[1,5-c]pyrimidin-2-thiones (4-6, 10) and 3-benzyl-5-methyl thiazolo[5,4-e]pyrimidino[3,4-b][1,...

journal_title：Archives of pharmacal research

authors： Said M,Abouzid K,Mouneer A,Ahmedy A,Osman AM

更新日期：2004-05-01 00:00:00

abstract：:An efficient analytical method was devised for the accurate L-muscone assay in aqueous samples. It involves solid-phase extraction of L-muscone in adsorption mode using XAD-4 as the sorbent and dichloromethane modified with 10% (v/v) methanol as the eluting solvent. The gas chromatographic analysis of the eluate resid...

journal_title：Archives of pharmacal research

authors： Paik MJ,Kim KR

更新日期：2004-05-01 00:00:00

abstract：:Five pentacyclic triterpenoids, oleanolic acid (1), hederagenin (2), ursolic acid (3), tormentic acid (4) and myrianthic acid (5), were isolated from the methanol extract of the leaves of Campsis grandiflora, and structures of the compounds were established by the spectroscopic methods. Compounds 2, 3, 4, and 5 were i...

journal_title：Archives of pharmacal research

authors： Jin JL,Lee YY,Heo JE,Lee S,Kim JM,Yun-Choi HS

更新日期：2004-04-01 00:00:00

abstract：:SJ compounds (SJ8002 and related compounds) are a group of novel anticancer agents (Cho, Chung, Lee, Kwon, Kang, Joo, and Oh. PCT/KR02/00392). To explore the anticancer mechanism of these compounds, we examined the effect of SJ8002 on microtubules of six human cell lines. At a high concentration (2 microg/mL), SJ8002 ...

journal_title：Archives of pharmacal research

authors： Lee JH,Kang DW,Kwon HS,Lee SH,Park SK,Chung SG,Cho EH,Paik SY,Lee JH

更新日期：2004-04-01 00:00:00

abstract：:A number of 8-arylflavones have been synthesized as congeners of wogonin and evaluated for their inhibitory activities of PGE2 production. 8-Arylflavones were obtained from commercially available chrysin via two different synthetic pathways. Most 8-arylflavones exhibited much reduced inhibitory activities against COX-...

journal_title：Archives of pharmacal research

authors： Dao TT,Kim SB,Sin KS,Kim S,Kim HP,Park H

更新日期：2004-03-01 00:00:00

abstract：:In this study, the effects of (-)-epigallocatechin-3-gallate (EGCG) and/or hinokitiol (beta-thujaplicin) on melanogenesis were investigated. Our results showed that both EGCG and hinokitiol significantly inhibited melanin synthesis in a concentration-dependent manner, and that their hypopigmenting effects were stronge...

journal_title：Archives of pharmacal research

authors： Kim DS,Park SH,Kwon SB,Li K,Youn SW,Park KC

更新日期：2004-03-01 00:00:00

abstract：:The pharmacokinetics of CKD-732 (6-O-4-[dimethyl-aminoethoxy)cinnamoyl]-fumagillol x hemioxalate) was investigated in male SD rats and beagle dogs after bolus intravenous administration. The parent compound and metabolites obtained from in vitro and in vivo samples were determined by LC/MS. The main metabolite was iso...

journal_title：Archives of pharmacal research

authors： Lee HS,Choi WK,Son HJ,Lee SS,Kim JK,Ahn SK,Hong CI,Min HK,Kim M,Myung SW

更新日期：2004-02-01 00:00:00

abstract：:The present study was carried out to clarify whether tectorigenin and tectoridin isolated from the rhizomes of Belamcanda chinensis (Iridaceae) inhibit hepatic damage induced by carbon tetrachloride (CCl4)-intoxication in rats by the experimental methods in vitro and in vivo. Tectorigenin and tectoridin exhibited a si...

journal_title：Archives of pharmacal research

authors： Jung SH,Lee YS,Lim SS,Lee S,Shin KH,Kim YS

更新日期：2004-02-01 00:00:00

abstract：:The purpose of this study was to investigate the pharmacokinetic alteration of diltiazem and its main metabolite, deacetyldiltiazem, after oral administration of diltiazem in rabbits with or without cimetidine co-administration. The area under the plasma concentration-time curve (AUC) of diltiazem was significantly el...

journal_title：Archives of pharmacal research

authors： Choi JS,Burm JP

更新日期：2004-02-01 00:00:00

abstract：:Initial burst is one of the major challenges in protein-encapsulated microparticle systems. Since protein release during the initial stage depends mostly on the diffusional escape of the protein, major approaches to prevent the initial burst have focused on efficient encapsulation of the protein within the micropartic...

journal_title：Archives of pharmacal research

authors： Yeo Y,Park K

更新日期：2004-01-01 00:00:00

abstract：:Glycyrrhizin (18beta-glycyrrhetinic acid-3-O-beta-D-glucuronopyranosyl-(1 --> 2)-beta-D-glucuronide, GL) was transformed to 18beta-glycyrrhetinic acid-3-O-beta-D-glucuronide (GAMG) by Streptococcus LJ-22. The antiallergic activities of GL and GAMG was measured using a RBL cell assay system and contact hypersensitivity...

journal_title：Archives of pharmacal research

authors： Park HY,Park SH,Yoon HK,Han MJ,Kim DH

更新日期：2004-01-01 00:00:00

abstract：:The aqueous extract of European mistletoe (Viscum album, L.) has been used in cancer therapy. The purified mistletoe lectins, main components of mistletoe, have demonstrated cytotoxic and immune-system-stimulating activities. Korean mistletoe (Viscum album L. coloratum), a subspecies of European mistletoe, has also be...

journal_title：Archives of pharmacal research

authors： Lyu SY,Kwon YJ,Joo HJ,Park WB

更新日期：2004-01-01 00:00:00

abstract：:This paper deals with chiral enzymatic resolution of 4-arylthio-2-butanols by lipase to prepare potential intermediates of beta-lactam antibiotics. Among several lipases employed, lipase P type enzyme gave the highest ee value to prepare (R)-4-arylthio-2-butyl acetate. The enzymatic resolution of phenyl substituted al...

journal_title：Archives of pharmacal research

authors： Hwang KJ,Lee J,Chin S,Moon CJ,Lee W,Baek CS,Kim HJ

更新日期：2003-12-01 00:00:00

abstract：:Lysophosphatidic acid (LPA) is a well-known mitogen in various cell types. However, we found that LPA inhibits melanocyte proliferation. Thus, we further investigated the possible signaling pathways involved in melanocyte growth inhibition. We first examined the regulation of the three major subfamilies of mitogen-act...

journal_title：Archives of pharmacal research

authors： Kim DS,Park SH,Kim SE,Kwon SB,Park ES,Youn SW,Park KC

更新日期：2003-12-01 00:00:00

abstract：:Nitric oxide(NO) induces apoptosis in human osteoblasts. Treatment with exogenous NO donors, SNAP (S-Nitroso-N-acetylpenicillamine) and SNP (sodium nitroprusside), to MG-63 osteoblasts resulted in apoptotic morphological changes, as shown by a bright blue-fluorescent condensed nuclei and chromatin fragmentation by flu...

journal_title：Archives of pharmacal research

authors： Kang YJ,Chae SW

更新日期：2003-11-01 00:00:00

abstract：:The effects of purple sweet potato anthocyanin (SPA) and Cordyceps mushroom extract (CME) on lipid peroxidation, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals and cognitive deficits were examined. Both SPA and CME exhibited DPPH radical scavenging activities with similar potency. In contrast, only SPA was shown to eff...

journal_title：Archives of pharmacal research

authors： Cho J,Kang JS,Long PH,Jing J,Back Y,Chung KS

更新日期：2003-10-01 00:00:00

abstract：:Five coumarins, isoimperatorin (1), pabulenol (2), isooxypeucedanin (3), oxypeucedanin hydrate (4) and osthol (5) were isolated from the MeOH extract of Angelica genuflexa in the course of searching for anti-platelet and anti-coagulant components from plants. Pabulenol (2) was isolated from A. genuflexa for the first ...

journal_title：Archives of pharmacal research

authors： Lee YY,Lee S,Jin JL,Yun-Choi HS

更新日期：2003-09-01 00:00:00

abstract：:Activity-guided fractionation of the EtOAc-soluble extract of the whole plants of Sida acuta using a bioassay based on the induction of quinone reductase (QR) in cultured Hepa 1c1c7 mouse hepatoma cells, led to the isolation of ten active compounds of previously known structure, quindolinone (1), cryptolepinone (2), 1...

journal_title：Archives of pharmacal research

authors： Jang DS,Park EJ,Kang YH,Su BN,Hawthorne ME,Vigo JS,Graham JG,Cabieses F,Fong HH,Mehta RG,Pezzuto JM,Kinghorn AD

更新日期：2003-08-01 00:00:00

abstract：:To investigate the feasibility of developing a new ondansetron transdermal system, the effects of vehicles and penetration enhancers on the in vitro permeation of ondansetron hydrochloride (OS) from a pressure-sensitive adhesive (PSA) matrices across dorsal hairless mouse skin were studied. Vehicles employed in this s...

journal_title：Archives of pharmacal research

authors： Gwak HS,Oh IS,Chun IK

更新日期：2003-08-01 00:00:00

abstract：:Quinazolinones, 2-substituted and 3-substituted, mainly synthesized by microwave irradiation, were subjected to anti-platelet aggregation and inhibition of superoxide anion generation assays. Interestingly, 2-phenyl-4-quinazolinone (4) exhibited significant inhibitory activities toward platelet aggregation and neutrop...

journal_title：Archives of pharmacal research

authors： Chang FR,Wu CC,Hwang TL,Patnam R,Kuo RY,Wang WY,Lan YH,Wu YC

更新日期：2003-07-01 00:00:00

abstract：:Pharmacokinetic and pharmacodynamic properties of gliclazide were studied after an oral administration of gliclazide tablets in healthy volunteers. After an overnight fasting, gliclazide tablet was orally administered to 11 volunteers. Additional 10 volunteers were used as a control group (i.e., no gliclazide administ...

journal_title：Archives of pharmacal research

authors： Kim H,Yun M,Kwon KI

更新日期：2003-07-01 00:00:00

abstract：:New sulfonated amino ribofuranans were synthesized to elucidate the relationship between structure and specific biological activities such as anti-HIV and blood anticoagulant activities. The synthesis was performed by sulfonation of copolymers having various proportion of (1 --> 5)-alpha-D-ribofuranosidic unit. The su...

journal_title：Archives of pharmacal research

authors： Kang BW

更新日期：2003-06-01 00:00:00

abstract：:This study investigated the effects of extremely low frequency magnetic fields (ELF-MFs) on the sensitivity of seizure response to bicuculline, picrotoxin and NMDA in mice. The mice were exposed to either a sham or 20 G ELF-MFs for 24 hours. Convulsants were then administered i.p. at various doses. The seizure inducti...

journal_title：Archives of pharmacal research

authors： Sung JH,Jeong JH,Kim JS,Choi TS,Park JH,Kang HY,Kim YS,Kim DS,Sohn UD

更新日期：2003-06-01 00:00:00

abstract：:Five kinds of allylthiopyridazine derivatives were synthesized and their chemoprotective activities examined in rats exposed to aflatoxin B1-toxicant. Rats were pretreated with five allylthiopyridazine derivatives at daily oral doses of 50 mg/kg for 10 consecutive days, and during this period with one or three repeate...

journal_title：Archives of pharmacal research

authors： Shin HS,Kwon SK

更新日期：2003-05-01 00:00:00

abstract：:The aim of the present study was to evaluate the effects of two phospholipid permeation enhancers, lysophosphatidylcholine (LPC) and didecanoylphosphatidylcholine (DDPC), along with a fusidic acid derivative, sodium taurodihydrofusidate (STDHF) and ethanol (EtOH) on the buccal transport of propranolol hydrochloride (P...

journal_title：Archives of pharmacal research

authors： Lee J,Choi YW

更新日期：2003-05-01 00:00:00

abstract：:Resveratrol analogs were newly synthesized and evaluated for cytotoxicity in cultured human lung and colon cancer cells. 3,5,4-Trimethoxy-trans-stilbene and 3,5,2',4'-tetramethoxy-trans-stilbene were found to be more potent rather than resveratrol. 3,4,5-Trimethoxy-4'-bromo-cis-stilbene was the most active among the t...

journal_title：Archives of pharmacal research

authors： Lee SK,Nam KA,Hoe YH,Min HY,Kim EY,Ko H,Song S,Lee T,Kim S

更新日期：2003-04-01 00:00:00

abstract：:The oriental herbal combination allergina has been shown to inhibit allergic inflammation. In the present study, we demonstrate that the oral administration of allergina markedly inhibits the progression of inflammatory diseases, such as graft-versus-host diseases (in the allogeneic bone marrow transplantation and the...

journal_title：Archives of pharmacal research

authors： Han SB,Lee CW,Park SK,Yoon WK,Moon JS,Lee KH,Kim HC,Kim HM

更新日期：2003-04-01 00:00:00

abstract：:This study describes the synthesis of novel enol esters (3) and triketones (4) as analogues of succinylacetone (SA) (Ed- this abbreviation is introduced here based on your use of it in the body of the paper) and the evaluation on the mouse allogeneic mixed lymphocyte reaction (MLR) and the murine model of antigen-indu...

journal_title：Archives of pharmacal research

authors： Kim TH,Oh DR,Na HS,Lee HC

更新日期：2003-03-01 00:00:00

abstract：:From the pulp of Euphoria longana (Longan Arillus), three cerebroside molecular species have been isolated. Six known cerebrosides, soyacerebrosides I and II, 1-O-beta-D-glucopyranosyl-(2S,3R,4E,8E)-2-(2'-lignoceroylamino)-4,8-octadecadiene-1,3-diol (longan cerebroside I) and its 8Z isomer (longan cerebroside II), mom...

journal_title：Archives of pharmacal research

authors： Ryu J,Kim JS,Kang SS

更新日期：2003-02-01 00:00:00

abstract：:For probing the importance of planarity of imidazolidinone motif of 4-phenyl-1-(benzenesulfonyl)imidazolidinones 1 for their cytotoxicity, 4-phenyl-2-(benzoyl)[1,2,5]thiadiazolidine-1,1-dioxide (2a), 4-phenyl-2-(p-toluoyl)[1,2,5]thiadiazolidine-1,1-dioxide (2b), 4-phenyl-2-(phenylcarbamoyl)[1,2,5]thiadiazolidine-1,1-d...

journal_title：Archives of pharmacal research

authors： Kim IW,Lee CK,Kim HS,Jung SH

更新日期：2003-01-01 00:00:00